Closer to a Cure for Cystic Fibrosis Essays -- Proteasomes Cystic Fibr

Overcoming Proteasomes One Step Closer to a Cure for cystic FibrosisTake a deep breath and consider how easy it was to do so. Now picture struggling andgasping for air everyday normal, easy tasks to the average soul prove to be quite challengingto a patient of cystic fibrosis. Scientists have always been daunted by this fatal divisortic diseasethat affects the system by excreting a thick mucus in the lungs, making breathing difficult andblocking the ducts leading from the pancreas, causing poor digestion of food (1). Untilrecently, on that point was nothing that scientists could do to provide a long-term cure, but even thoughscientists cannot cure patients one hundred percent, they can increase their life expectancy. disdain having discovered the cystic fibrosis genes location in 1989, numerous underlyingobstacles prevent complete success (2). The primary obstacle that prevents scientists frommaking gene therapy an effective cure is the placement of the healthy genes into long-te rm cells,the cells that remain long enough to be replicated. The replacement of the healthy gene intolong-term cells is necessary because these cells build the new cells, thereby distributing thehealthy DNA throughout the body. The properly functioning gene is attached to a vector orcarrying molecule that will broadcast the therapeutic gene to the patients target cells (2).Currently, the most common vector is a virus because it can easily capture the gene and represent itinto the cell the virus infiltrates the corrupt cells and places the healthy gene into the nucleuswhich then transforms the corrupt cell into one which operates properly (2). The only difficultyis that the bodys natural immune system provides many b... ...t-education/tips/ccysfibr.html.2. Institute NHGR. Gene Therapy Internet. 2007 2007 phratry 18 Available from.3. Stefano Ferrari DMG, Eric WFW Alton. Barriers to and new approaches for gene therapyand gene delivery in cystic fibrosis. move on Drug Delivery Rev iews 200264 1373-1393.4. J Kim C-PC, KG Rice. The proteasome metabolizes peptide-mediated nonviral genedelivery systems. Gene Therapy 2006 12 1681-1690.5. Neil Campbell, and Lawrence Mitchell (1999). Biology. New York, Addison WesleyLongman, Inc.6. Institute NHGR. Learning About Cystic Fibrosis Internet. 2007 2007 September 18Available from .7. U Griesenbach DG, and EWFW alton. Gene therapy progress and prospects cysticfibrosis. Gene Therapy 2007 13 1071-1077.